![]() ![]() Furthermore, the literature presents a wide array of methods and guidelines with respect to the use of local antimicrobials. Local antimicrobial therapy has been widely studied in periprosthetic joint infection, without addressing the specific problems of FRI. For this reason, the use of locally delivered antimicrobials has gained attention not only for local antimicrobial activity but also for dead space management. Dead space management is therefore of critical importance. However, debridement is often associated with the formation of a dead space, which provides an ideal environment for bacteria and is a potential site for recurrent infection. Treatment success is associated with debridement of all dead and poorly vascularized tissue. ![]() The surgical management eradicates the local infectious focus and if necessary facilitates bone healing. Summary:Fracture-related infection (FRI) remains a challenging complication that imposes a heavy burden on orthopaedic trauma patients.
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